diff --git a/lib/adapters/http.js b/lib/adapters/http.js
index 063be60f..b9981159 100755
--- a/lib/adapters/http.js
+++ b/lib/adapters/http.js
@@ -23,6 +23,7 @@ import formDataToStream from '../helpers/formDataToStream.js';
 import readBlob from '../helpers/readBlob.js';
 import ZlibHeaderTransformStream from '../helpers/ZlibHeaderTransformStream.js';
 import callbackify from '../helpers/callbackify.js';
+import shouldBypassProxy from '../helpers/shouldBypassProxy.js';
 import {
   progressEventReducer,
   progressEventDecorator,
@@ -192,7 +193,9 @@ function setProxy(options, configProxy, location) {
   if (!proxy && proxy !== false) {
     const proxyUrl = getProxyForUrl(location);
     if (proxyUrl) {
-      proxy = new URL(proxyUrl);
+      if (!shouldBypassProxy(location)) {
+        proxy = new URL(proxyUrl);
+      }
     }
   }
   if (proxy) {
diff --git a/lib/helpers/shouldBypassProxy.js b/lib/helpers/shouldBypassProxy.js
new file mode 100644
index 00000000..2460695d
--- /dev/null
+++ b/lib/helpers/shouldBypassProxy.js
@@ -0,0 +1,106 @@
+const DEFAULT_PORTS = {
+  http: 80,
+  https: 443,
+  ws: 80,
+  wss: 443,
+  ftp: 21,
+};
+
+const parseNoProxyEntry = (entry) => {
+  let entryHost = entry;
+  let entryPort = 0;
+
+  if (entryHost.charAt(0) === '[') {
+    const bracketIndex = entryHost.indexOf(']');
+
+    if (bracketIndex !== -1) {
+      const host = entryHost.slice(1, bracketIndex);
+      const rest = entryHost.slice(bracketIndex + 1);
+
+      if (rest.charAt(0) === ':' && /^\d+$/.test(rest.slice(1))) {
+        entryPort = Number.parseInt(rest.slice(1), 10);
+      }
+
+      return [host, entryPort];
+    }
+  }
+
+  const firstColon = entryHost.indexOf(':');
+  const lastColon = entryHost.lastIndexOf(':');
+
+  if (
+    firstColon !== -1 &&
+    firstColon === lastColon &&
+    /^\d+$/.test(entryHost.slice(lastColon + 1))
+  ) {
+    entryPort = Number.parseInt(entryHost.slice(lastColon + 1), 10);
+    entryHost = entryHost.slice(0, lastColon);
+  }
+
+  return [entryHost, entryPort];
+};
+
+const normalizeNoProxyHost = (hostname) => {
+  if (!hostname) {
+    return hostname;
+  }
+
+  if (hostname.charAt(0) === '[' && hostname.charAt(hostname.length - 1) === ']') {
+    hostname = hostname.slice(1, -1);
+  }
+
+  return hostname.replace(/\.+$/, '');
+};
+
+export default function shouldBypassProxy(location) {
+  let parsed;
+
+  try {
+    parsed = new URL(location);
+  } catch (_err) {
+    return false;
+  }
+
+  const noProxy = (process.env.no_proxy || process.env.NO_PROXY || '').toLowerCase();
+
+  if (!noProxy) {
+    return false;
+  }
+
+  if (noProxy === '*') {
+    return true;
+  }
+
+  const port =
+    Number.parseInt(parsed.port, 10) || DEFAULT_PORTS[parsed.protocol.split(':', 1)[0]] || 0;
+
+  const hostname = normalizeNoProxyHost(parsed.hostname.toLowerCase());
+
+  return noProxy.split(/[\s,]+/).some((entry) => {
+    if (!entry) {
+      return false;
+    }
+
+    let [entryHost, entryPort] = parseNoProxyEntry(entry);
+
+    entryHost = normalizeNoProxyHost(entryHost);
+
+    if (!entryHost) {
+      return false;
+    }
+
+    if (entryPort && entryPort !== port) {
+      return false;
+    }
+
+    if (entryHost.charAt(0) === '*') {
+      entryHost = entryHost.slice(1);
+    }
+
+    if (entryHost.charAt(0) === '.') {
+      return hostname.endsWith(entryHost);
+    }
+
+    return hostname === entryHost;
+  });
+}
diff --git a/tests/unit/adapters/http.test.js b/tests/unit/adapters/http.test.js
index c776c881..73fe7af5 100644
--- a/tests/unit/adapters/http.test.js
+++ b/tests/unit/adapters/http.test.js
@@ -1738,6 +1738,114 @@ describe('supports http with nodejs', () => {
     }
   });
 
+  it('should not use proxy for localhost with trailing dot when listed in no_proxy', async () => {
+    const originalHttpProxy = process.env.http_proxy;
+    const originalHTTPProxy = process.env.HTTP_PROXY;
+    const originalNoProxy = process.env.no_proxy;
+    const originalNOProxy = process.env.NO_PROXY;
+
+    let proxyRequests = 0;
+    const proxy = await startHTTPServer(
+      (_, response) => {
+        proxyRequests += 1;
+        response.end('proxied');
+      },
+      { port: PROXY_PORT }
+    );
+
+    const noProxyValue = 'localhost,127.0.0.1,::1';
+    const proxyUrl = `http://localhost:${proxy.address().port}/`;
+    process.env.http_proxy = proxyUrl;
+    process.env.HTTP_PROXY = proxyUrl;
+    process.env.no_proxy = noProxyValue;
+    process.env.NO_PROXY = noProxyValue;
+
+    try {
+      await assert.rejects(axios.get('http://localhost.:1/', { timeout: 100 }));
+      assert.equal(proxyRequests, 0, 'should not use proxy for localhost with trailing dot');
+    } finally {
+      await stopHTTPServer(proxy);
+
+      if (originalHttpProxy === undefined) {
+        delete process.env.http_proxy;
+      } else {
+        process.env.http_proxy = originalHttpProxy;
+      }
+
+      if (originalHTTPProxy === undefined) {
+        delete process.env.HTTP_PROXY;
+      } else {
+        process.env.HTTP_PROXY = originalHTTPProxy;
+      }
+
+      if (originalNoProxy === undefined) {
+        delete process.env.no_proxy;
+      } else {
+        process.env.no_proxy = originalNoProxy;
+      }
+
+      if (originalNOProxy === undefined) {
+        delete process.env.NO_PROXY;
+      } else {
+        process.env.NO_PROXY = originalNOProxy;
+      }
+    }
+  });
+
+  it('should not use proxy for bracketed IPv6 loopback when listed in no_proxy', async () => {
+    const originalHttpProxy = process.env.http_proxy;
+    const originalHTTPProxy = process.env.HTTP_PROXY;
+    const originalNoProxy = process.env.no_proxy;
+    const originalNOProxy = process.env.NO_PROXY;
+
+    let proxyRequests = 0;
+    const proxy = await startHTTPServer(
+      (_, response) => {
+        proxyRequests += 1;
+        response.end('proxied');
+      },
+      { port: PROXY_PORT }
+    );
+
+    const noProxyValue = 'localhost,127.0.0.1,::1';
+    const proxyUrl = `http://localhost:${proxy.address().port}/`;
+    process.env.http_proxy = proxyUrl;
+    process.env.HTTP_PROXY = proxyUrl;
+    process.env.no_proxy = noProxyValue;
+    process.env.NO_PROXY = noProxyValue;
+
+    try {
+      await assert.rejects(axios.get('http://[::1]:1/', { timeout: 100 }));
+      assert.equal(proxyRequests, 0, 'should not use proxy for IPv6 loopback');
+    } finally {
+      await stopHTTPServer(proxy);
+
+      if (originalHttpProxy === undefined) {
+        delete process.env.http_proxy;
+      } else {
+        process.env.http_proxy = originalHttpProxy;
+      }
+
+      if (originalHTTPProxy === undefined) {
+        delete process.env.HTTP_PROXY;
+      } else {
+        process.env.HTTP_PROXY = originalHTTPProxy;
+      }
+
+      if (originalNoProxy === undefined) {
+        delete process.env.no_proxy;
+      } else {
+        process.env.no_proxy = originalNoProxy;
+      }
+
+      if (originalNOProxy === undefined) {
+        delete process.env.NO_PROXY;
+      } else {
+        process.env.NO_PROXY = originalNOProxy;
+      }
+    }
+  });
+
   it('should use proxy for domains not in no_proxy', async () => {
     const originalHttpProxy = process.env.http_proxy;
     const originalHTTPProxy = process.env.HTTP_PROXY;
diff --git a/tests/unit/helpers/shouldBypassProxy.test.js b/tests/unit/helpers/shouldBypassProxy.test.js
new file mode 100644
index 00000000..0879cceb
--- /dev/null
+++ b/tests/unit/helpers/shouldBypassProxy.test.js
@@ -0,0 +1,52 @@
+import { afterEach, describe, expect, it } from 'vitest';
+import shouldBypassProxy from '../../../lib/helpers/shouldBypassProxy.js';
+
+const originalNoProxy = process.env.no_proxy;
+const originalNOProxy = process.env.NO_PROXY;
+
+const setNoProxy = (value) => {
+  process.env.no_proxy = value;
+  process.env.NO_PROXY = value;
+};
+
+afterEach(() => {
+  if (originalNoProxy === undefined) {
+    delete process.env.no_proxy;
+  } else {
+    process.env.no_proxy = originalNoProxy;
+  }
+
+  if (originalNOProxy === undefined) {
+    delete process.env.NO_PROXY;
+  } else {
+    process.env.NO_PROXY = originalNOProxy;
+  }
+});
+
+describe('helpers::shouldBypassProxy', () => {
+  it('should bypass proxy for localhost with a trailing dot', () => {
+    setNoProxy('localhost,127.0.0.1,::1');
+
+    expect(shouldBypassProxy('http://localhost.:8080/')).toBe(true);
+  });
+
+  it('should bypass proxy for bracketed ipv6 loopback', () => {
+    setNoProxy('localhost,127.0.0.1,::1');
+
+    expect(shouldBypassProxy('http://[::1]:8080/')).toBe(true);
+  });
+
+  it('should support bracketed ipv6 entries in no_proxy', () => {
+    setNoProxy('[::1]');
+
+    expect(shouldBypassProxy('http://[::1]:8080/')).toBe(true);
+  });
+
+  it('should match wildcard and explicit ports', () => {
+    setNoProxy('*.example.com,localhost:8080');
+
+    expect(shouldBypassProxy('http://api.example.com/')).toBe(true);
+    expect(shouldBypassProxy('http://localhost:8080/')).toBe(true);
+    expect(shouldBypassProxy('http://localhost:8081/')).toBe(false);
+  });
+});