diff --git a/PRE_RELEASE_CHANGELOG.md b/PRE_RELEASE_CHANGELOG.md
index b182213a..9abc1394 100644
--- a/PRE_RELEASE_CHANGELOG.md
+++ b/PRE_RELEASE_CHANGELOG.md
@@ -9,6 +9,7 @@
 ## Bug Fixes
 
 - **AxiosHeaders:** Silently skip empty response header names emitted by some React Native Android responses instead of throwing. (**#6959**, **#10875**)
+- **React Native FormData:** Clear the default `Content-Type` header for React Native `FormData` requests so Android can build multipart bodies with the correct boundary. (**#10898**)
 - **Request Data:** Preserve enumerable symbol keys when merging plain request data before `transformRequest`. (**#6392**)
 
 ## Release Documentation TODO
diff --git a/lib/helpers/resolveConfig.js b/lib/helpers/resolveConfig.js
index 2e9b4b0b..ea9d346a 100644
--- a/lib/helpers/resolveConfig.js
+++ b/lib/helpers/resolveConfig.js
@@ -70,8 +70,12 @@ function resolveConfig(config) {
   }
 
   if (utils.isFormData(data)) {
-    if (platform.hasStandardBrowserEnv || platform.hasStandardBrowserWebWorkerEnv) {
-      headers.setContentType(undefined); // browser handles it
+    if (
+      platform.hasStandardBrowserEnv ||
+      platform.hasStandardBrowserWebWorkerEnv ||
+      utils.isReactNative(data)
+    ) {
+      headers.setContentType(undefined); // browser/web worker/RN handles it
     } else if (utils.isFunction(data.getHeaders)) {
       // Node.js FormData (like form-data package)
       setFormDataHeaders(headers, data.getHeaders(), own('formDataHeaderPolicy'));
diff --git a/tests/unit/core/dispatchRequest.test.js b/tests/unit/core/dispatchRequest.test.js
index b2416a3a..11237f59 100644
--- a/tests/unit/core/dispatchRequest.test.js
+++ b/tests/unit/core/dispatchRequest.test.js
@@ -3,6 +3,19 @@ import assert from 'assert';
 import dispatchRequest from '../../../lib/core/dispatchRequest.js';
 import AxiosError from '../../../lib/core/AxiosError.js';
 import defaults from '../../../lib/defaults/index.js';
+import resolveConfig from '../../../lib/helpers/resolveConfig.js';
+
+class ReactNativeFormData {
+  append() {}
+
+  getParts() {
+    return [];
+  }
+
+  get [Symbol.toStringTag]() {
+    return 'FormData';
+  }
+}
 
 function baseConfig(overrides = {}) {
   return {
@@ -122,6 +135,45 @@ describe('core::dispatchRequest', () => {
   });
 
   describe('happy path', () => {
+    it('clears default Content-Type for React Native FormData before adapter headers are sent', async () => {
+      const data = new ReactNativeFormData();
+      const response = {
+        data: '{"ok":true}',
+        status: 200,
+        statusText: 'OK',
+        headers: {},
+        config: null,
+        request: {},
+      };
+      const config = baseConfig({
+        method: 'post',
+        data,
+        adapter: (adapterConfig) => {
+          assert.strictEqual(
+            adapterConfig.headers.getContentType(),
+            'application/x-www-form-urlencoded',
+            'dispatchRequest should apply the default POST Content-Type first'
+          );
+
+          const resolvedConfig = resolveConfig(adapterConfig);
+
+          assert.strictEqual(resolvedConfig.data, data);
+          assert.strictEqual(resolvedConfig.headers.getContentType(), undefined);
+          assert.strictEqual(
+            Object.prototype.hasOwnProperty.call(resolvedConfig.headers.toJSON(), 'Content-Type'),
+            false,
+            'resolved adapter headers must omit Content-Type for React Native FormData'
+          );
+
+          return Promise.resolve(response);
+        },
+      });
+
+      const result = await dispatchRequest(config);
+
+      assert.deepStrictEqual(result.data, { ok: true });
+    });
+
     it('cleans up config.response after a successful resolution', async () => {
       const response = {
         data: '{"ok":true}',
diff --git a/tests/unit/helpers/resolveConfig.test.js b/tests/unit/helpers/resolveConfig.test.js
new file mode 100644
index 00000000..9ee95f75
--- /dev/null
+++ b/tests/unit/helpers/resolveConfig.test.js
@@ -0,0 +1,35 @@
+import { describe, it } from 'vitest';
+import assert from 'assert';
+import resolveConfig from '../../../lib/helpers/resolveConfig.js';
+
+class ReactNativeFormData {
+  append() {}
+
+  getParts() {
+    return [];
+  }
+
+  get [Symbol.toStringTag]() {
+    return 'FormData';
+  }
+}
+
+describe('helpers::resolveConfig', () => {
+  it('clears Content-Type for React Native FormData', () => {
+    const data = new ReactNativeFormData();
+    const config = resolveConfig({
+      url: '/upload',
+      data,
+      headers: {
+        'Content-Type': 'application/x-www-form-urlencoded',
+      },
+    });
+
+    assert.strictEqual(config.data, data);
+    assert.strictEqual(config.headers.getContentType(), undefined);
+    assert.strictEqual(
+      Object.prototype.hasOwnProperty.call(config.headers.toJSON(), 'Content-Type'),
+      false
+    );
+  });
+});