diff --git a/fastpath.go b/fastpath.go
index 06e1354a..f8af6190 100644
--- a/fastpath.go
+++ b/fastpath.go
@@ -76,6 +76,8 @@ func (f *fastpath) Call(oid pgtype.OID, args []fpArg) (res []byte, err error) {
 		return nil, err
 	}
 
+	f.cn.pendingReadyForQueryCount++
+
 	for {
 		msg, err := f.cn.rxMsg()
 		if err != nil {
diff --git a/large_objects_test.go b/large_objects_test.go
index a19c851d..1d0a4f32 100644
--- a/large_objects_test.go
+++ b/large_objects_test.go
@@ -119,3 +119,147 @@ func TestLargeObjects(t *testing.T) {
 		t.Errorf("Expected undefined_object error (42704), got %#v", err)
 	}
 }
+
+func TestLargeObjectsMultipleTransactions(t *testing.T) {
+	t.Parallel()
+
+	conn, err := pgx.Connect(*defaultConnConfig)
+	if err != nil {
+		t.Fatal(err)
+	}
+
+	tx, err := conn.Begin()
+	if err != nil {
+		t.Fatal(err)
+	}
+
+	lo, err := tx.LargeObjects()
+	if err != nil {
+		t.Fatal(err)
+	}
+
+	id, err := lo.Create(0)
+	if err != nil {
+		t.Fatal(err)
+	}
+
+	obj, err := lo.Open(id, pgx.LargeObjectModeWrite)
+	if err != nil {
+		t.Fatal(err)
+	}
+
+	n, err := obj.Write([]byte("testing"))
+	if err != nil {
+		t.Fatal(err)
+	}
+	if n != 7 {
+		t.Errorf("Expected n to be 7, got %d", n)
+	}
+
+	// Commit the first transaction
+	err = tx.Commit()
+	if err != nil {
+		t.Fatal(err)
+	}
+
+	// IMPORTANT: Use the same connection for another query
+	query := `select n from generate_series(1,10) n`
+	rows, err := conn.Query(query)
+	if err != nil {
+		t.Fatal(err)
+	}
+	rows.Close()
+
+	// Start a new transaction
+	tx2, err := conn.Begin()
+	if err != nil {
+		t.Fatal(err)
+	}
+
+	lo2, err := tx2.LargeObjects()
+	if err != nil {
+		t.Fatal(err)
+	}
+
+	// Reopen the large object in the new transaction
+	obj2, err := lo2.Open(id, pgx.LargeObjectModeRead|pgx.LargeObjectModeWrite)
+	if err != nil {
+		t.Fatal(err)
+	}
+
+	pos, err := obj2.Seek(1, 0)
+	if err != nil {
+		t.Fatal(err)
+	}
+	if pos != 1 {
+		t.Errorf("Expected pos to be 1, got %d", pos)
+	}
+
+	res := make([]byte, 6)
+	n, err = obj2.Read(res)
+	if err != nil {
+		t.Fatal(err)
+	}
+	if string(res) != "esting" {
+		t.Errorf(`Expected res to be "esting", got %q`, res)
+	}
+	if n != 6 {
+		t.Errorf("Expected n to be 6, got %d", n)
+	}
+
+	n, err = obj2.Read(res)
+	if err != io.EOF {
+		t.Error("Expected io.EOF, go nil")
+	}
+	if n != 0 {
+		t.Errorf("Expected n to be 0, got %d", n)
+	}
+
+	pos, err = obj2.Tell()
+	if err != nil {
+		t.Fatal(err)
+	}
+	if pos != 7 {
+		t.Errorf("Expected pos to be 7, got %d", pos)
+	}
+
+	err = obj2.Truncate(1)
+	if err != nil {
+		t.Fatal(err)
+	}
+
+	pos, err = obj2.Seek(-1, 2)
+	if err != nil {
+		t.Fatal(err)
+	}
+	if pos != 0 {
+		t.Errorf("Expected pos to be 0, got %d", pos)
+	}
+
+	res = make([]byte, 2)
+	n, err = obj2.Read(res)
+	if err != io.EOF {
+		t.Errorf("Expected err to be io.EOF, got %v", err)
+	}
+	if n != 1 {
+		t.Errorf("Expected n to be 1, got %d", n)
+	}
+	if res[0] != 't' {
+		t.Errorf("Expected res[0] to be 't', got %v", res[0])
+	}
+
+	err = obj2.Close()
+	if err != nil {
+		t.Fatal(err)
+	}
+
+	err = lo2.Unlink(id)
+	if err != nil {
+		t.Fatal(err)
+	}
+
+	_, err = lo2.Open(id, pgx.LargeObjectModeRead)
+	if e, ok := err.(pgx.PgError); !ok || e.Code != "42704" {
+		t.Errorf("Expected undefined_object error (42704), got %#v", err)
+	}
+}