diff --git a/pgconn/pgconn.go b/pgconn/pgconn.go
index 311b06a3..a7c4eea3 100644
--- a/pgconn/pgconn.go
+++ b/pgconn/pgconn.go
@@ -562,8 +562,14 @@ func (pgConn *PgConn) RecoverFromTimeout(ctx context.Context) bool {
 	}
 	pgConn.resetBatch()
 
+	// Clear any existing timeout
 	pgConn.NetConn.SetDeadline(time.Time{})
 
+	// Try to cancel any in-progress requests
+	for i := 0; i < int(pgConn.pendingReadyForQueryCount); i++ {
+		pgConn.CancelRequest(ctx)
+	}
+
 	cleanupContext := contextDoneToConnDeadline(ctx, pgConn.NetConn)
 	defer cleanupContext()
 
@@ -669,3 +675,38 @@ func errorResponseToPgError(msg *pgproto3.ErrorResponse) PgError {
 		Routine:          msg.Routine,
 	}
 }
+
+// CancelRequest sends a cancel request to the PostgreSQL server. It returns an error if unable to deliver the cancel
+// request, but lack of an error does not ensure that the query was canceled. As specified in the documentation, there
+// is no way to be sure a query was canceled. See https://www.postgresql.org/docs/11/protocol-flow.html#id-1.10.5.7.9
+func (pgConn *PgConn) CancelRequest(ctx context.Context) error {
+	// Open a cancellation request to the same server. The address is taken from the net.Conn directly instead of reusing
+	// the connection config. This is important in high availability configurations where fallback connections may be
+	// specified or DNS may be used to load balance.
+	serverAddr := pgConn.NetConn.RemoteAddr()
+	cancelConn, err := pgConn.Config.DialFunc(ctx, serverAddr.Network(), serverAddr.String())
+	if err != nil {
+		return err
+	}
+	defer cancelConn.Close()
+
+	cleanupContext := contextDoneToConnDeadline(ctx, cancelConn)
+	defer cleanupContext()
+
+	buf := make([]byte, 16)
+	binary.BigEndian.PutUint32(buf[0:4], 16)
+	binary.BigEndian.PutUint32(buf[4:8], 80877102)
+	binary.BigEndian.PutUint32(buf[8:12], uint32(pgConn.PID))
+	binary.BigEndian.PutUint32(buf[12:16], uint32(pgConn.SecretKey))
+	_, err = cancelConn.Write(buf)
+	if err != nil {
+		return preferContextOverNetTimeoutError(ctx, err)
+	}
+
+	_, err = cancelConn.Read(buf)
+	if err != io.EOF {
+		return fmt.Errorf("Server failed to close connection after cancel query request: %v", preferContextOverNetTimeoutError(ctx, err))
+	}
+
+	return nil
+}
diff --git a/pgconn/pgconn_test.go b/pgconn/pgconn_test.go
index 98fd198e..9873013c 100644
--- a/pgconn/pgconn_test.go
+++ b/pgconn/pgconn_test.go
@@ -264,6 +264,8 @@ func TestConnExecContextCanceled(t *testing.T) {
 	result, err := pgConn.Exec(ctx, "select current_database(), pg_sleep(1)")
 	require.Nil(t, result)
 	assert.Equal(t, context.DeadlineExceeded, err)
+
+	assert.True(t, pgConn.RecoverFromTimeout(context.Background()))
 }
 
 func TestConnRecoverFromTimeout(t *testing.T) {
@@ -287,3 +289,23 @@ func TestConnRecoverFromTimeout(t *testing.T) {
 	}
 	cancel()
 }
+
+func TestConnCancelQuery(t *testing.T) {
+	pgConn, err := pgconn.Connect(context.Background(), os.Getenv("PGX_TEST_DATABASE"))
+	require.Nil(t, err)
+	defer closeConn(t, pgConn)
+
+	pgConn.SendExec("select current_database(), pg_sleep(5)")
+	err = pgConn.Flush(context.Background())
+	require.Nil(t, err)
+
+	err = pgConn.CancelRequest(context.Background())
+	require.Nil(t, err)
+
+	_, err = pgConn.GetResult(context.Background()).Close()
+	if err, ok := err.(pgconn.PgError); ok {
+		assert.Equal(t, "57014", err.Code)
+	} else {
+		t.Errorf("expected pgconn.PgError got %v", err)
+	}
+}